Sodium sulfoguaiacolate and process of making same.



UNIT-ED STAT -s WILLIAM CHARLES ALPERS, OF BAYONNE, NEW JERSEY.

SODIUM SULFOGUAIACOLATE AND PROCESS OF MAKING SAME.

SPECIFICATION formingpart of Letters latent No. 692,588, dated February 4, 1902.

Application filed May 8, 1901. Serial No. 59 319. (No specimens.)

To all whom it may-concern.-

Be it known that I, WILLIAM CHARLES AL- PERS, a citizen of the United States, and a resident of Bayonne, in the county of Hudson and State of New Jersey, have invented certain new and useful Improvements in the Manufacture of Guaiacol Derivatives, of which the followingis a f ull,clear,and exact description.

The object of the invention is to provide certain new and-useful improvements in the manufacture of guaiaool derivatives,whereby sodium sulfoguaiacolate or sodium orthoguaiacol-sulfonate is produced.

In order to prepare the product, I proceed as follows: Molecular quantities of guaiacol (O H .OOH,OH) and strong sulfuric acid (H 80 are mixed, and-the resulting thick red mass is dissolved in water, and calcium carbonate (02100 is then added in excess to form calcium sulfo-guaiacolate,

and to neutralize any free sulfuric acid that may be present. The solution of' calcium s'ulfo-guaiacolate is then filtered to free it from the precipitated calcium sulfate and treated with an equivalent quantity of sodium car bonate, (Na CO so that the calcium'carbonate (CaOO is precipitated and the sodium mains in solution. The solution isthen filtered and evaporated, and the sodium salt is deposited as a fine crystalline grayish-White powder. The product contains two'difterent guaiacol-sulfonic salts appearing as a'thick reddish syrupy mass. By treating this mass with ten times its quantity of absolute alcohol and cooling to zero grayish crystals are deposited, which by repeated Washing with alcoholcan be recrystallizedfrom distilled water as perfect white fine crystals. The motherliquor after distilling oi the alcohol again appears as a syrupy mass of a deeper color than before.

The reactions above described are expressed by the following formulae:

s. din.ooH,.oH.so, ,oa+Na,oo,=

2 0 1e,.ocn onso na oaco Sodium sulfo-guaiacolate or sodium orthoguaiacol-sulfonate is readily soluble in Water,- but sparingly soluble in alcohol and insoluble in ether. It has a slightly-bitter, followed by a somewhat sweetish, taste and is employed for the treatment of bronchial troubles, first stage of tuberculosis, and as an intestinal an tiseptic. The sodiu m sulfo-guaiacolate if pre cipitated from water appears as a grayishwhite powder, and if precipitated from alcohol it forms shining crystals. Its solution is colored violet upon the addition of tinctureof chlorid of iron. A head of the salt on plati-' num wire imparts a yellow color to the flame.

Having thus fully described my invention, I claim as new andde'sire to secure by Letters Patent- I 1. As a new article of manufacture, the

above described sodium sulfoguaiaoolate,"

which appears as a fine crystalline grayish white powder which dissolves readily in water but sparingly in alcohol, is insoluble inether, V and-its solution is colored violet upon the addition of tincture of chlorid'of iron. sulfo-guaiacolate (O H .OOH .OH.SO Na) re- .dium sulfo-guaiacolate, consisting in treating ;gu aiacol with sulfuric acid to for-ma thick red mass, subjecting this mass to the action of calcium carbonate, to form calcium sulfo 2 The process for the manufacture of soguaiacolate,precipitatin g the calcium sulfate, and thentreating the solution with sodium carbonate, to precipitate calcium" carbonate and to produce sodium sulfo-guaia'colatein solution, containing two different'guaiacol salts, and finally separating the two salts to produce sodium sulfo-guaiac'olate in crystalline form. v In testimony whereof I have signed my name to this specification in the presence of two subscribing witnesses.

WILLIAM CHARLES ALPERS. Witnesses: V

THEO. G. HOSTER, EVERARD B. MARSHALL. 

